Ticarcillin (sodium salt)
(2s,5r,6r)-6-[[(2r)-carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
CAS: 4697-14-7
Molecular Formula: C15H14N2Na2O6S2
Ticarcillin (sodium salt) - Names and Identifiers
Ticarcillin (sodium salt) - Physico-chemical Properties
| Molecular Formula | C15H14N2Na2O6S2 |
| Molar Mass | 428.39 |
| Melting Point | >173°C (dec.) |
| Solubility | H2O: soluble50mg/mL |
| Appearance | White solid |
| Color | white to light yellow |
| Merck | 13,9505 |
| Storage Condition | 2-8°C |
| Stability | Moisture sensitive |
| Physical and Chemical Properties | Opalescent non-crystalline powder with hygroscopicity. Readily soluble in water (>100g/mL), the pH of the resulting clear solution is 6.0-8.0. Aqueous solution is relatively stable; Acidic solution is relatively unstable. |
| In vitro study | Ticarcillin (64 mg/mL) for 90% of all β-lactamase-positive strains was reduced to 2 mg/mL on addition of clavulanic acid. Ticarcillin had a MICs of 4 mg/mL against 90% of all β-lactamase-negative strains. 93.4% of the β-lactamase producing strains were susceptible to Ticarcillin, with MICs less than or equal to 64 mg/ml. Ticarcillin/potassium clavulanate is photostable and resistant to inactivation by β-lactamase. Ticarcillin/potassium clavulanate is more economical than carbenicillin and cefotaxime in scavenging Agrobacterium tumefaciens at plant transformation. |
| In vivo study | The mean elimination half-life of Ticarcillin (120 mg/kg) in serum was 70.8 minutes in control subjects and 53.1 minutes in patients with cystic fibrosis. Systemic clearance of Ticarcillin was significantly higher in cystic fibrosis patients (65.6 mL/min/m2 vs 46.2 mL/min/m2 control subjects). The non-renal clearance of Ticarcillin was also significantly higher in cystic fibrosis patients (24.8 mL/min/m2 vs 13.3 mL/min/m2 controls). The clinical success and failure rates of Ticarcillin/clavulanate (3.1g,iv, administered every 4-6 hours) for the treatment of complicated skin and skin structure infections were 80.3 and 19.7, respectively. In the microbiologically evaluable population, the overall eradication rate in the Ticarcillin/clavulanate treatment group was 83.7 percent. In the final evaluation of the treatment of pediatric and adult patients with abdominal infection, Ticarcillin/clavulanate had a cure rate of 79%. |
Ticarcillin (sodium salt) - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42 - May cause sensitization by inhalation R43 - May cause sensitization by skin contact R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 2 |
| RTECS | XM9410000 |
Supplier List
Multiple SpecificationsSpot supply
Product Name: (2S,5R,6R)-Ticarcillin disodium Visit Supplier Webpage Request for quotationCAS: 4697-14-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Timentin Visit Supplier Webpage Request for quotationCAS: 4697-14-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Ticarcillin disodium salt Visit Supplier Webpage Request for quotationCAS: 4697-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Multiple SpecificationsSpot supply
Product Name: (2S,5R,6R)-Ticarcillin disodium Visit Supplier Webpage Request for quotationCAS: 4697-14-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Timentin Visit Supplier Webpage Request for quotationCAS: 4697-14-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Ticarcillin disodium salt Visit Supplier Webpage Request for quotationCAS: 4697-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Ticarcillin (sodium salt)
甲基异噻唑啉酮盐酸盐
5Α-REDUCTASE抑制剂(EPRISTERIDE)
Benzoic acid, 4-[(4-bromobenzoyl)oxy]-3-methoxy-, 4-octylphenyl ester
17beta-Hydroxyestr-4-en-3-one 17-(3-cyclopentylpropionate)
CHROMIC NITRATE NONAHYDRATE
Metronidazole Impurity (2-(2-Methyl-1H-imidazol-1-yl)ethanol hydrochloride)
过氧化-2-乙基己酸叔丁酯
乙氧甲酰基亚甲基三苯基膦
2-Propenamide
甲基异噻唑啉酮盐酸盐
5Α-REDUCTASE抑制剂(EPRISTERIDE)
Benzoic acid, 4-[(4-bromobenzoyl)oxy]-3-methoxy-, 4-octylphenyl ester
17beta-Hydroxyestr-4-en-3-one 17-(3-cyclopentylpropionate)
CHROMIC NITRATE NONAHYDRATE
Metronidazole Impurity (2-(2-Methyl-1H-imidazol-1-yl)ethanol hydrochloride)
过氧化-2-乙基己酸叔丁酯
乙氧甲酰基亚甲基三苯基膦
2-Propenamide